Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device
Identifieur interne : 002034 ( Main/Exploration ); précédent : 002033; suivant : 002035Testing objective measures of motor impairment in early Parkinson's disease: Feasibility study of an at‐home testing device
Auteurs : Christopher G. Goetz [États-Unis] ; Glenn T. Stebbins [États-Unis] ; David Wolff [États-Unis] ; William Deleeuw [États-Unis] ; Helen Bronte-Stewart [États-Unis] ; Rodger Elble [États-Unis] ; Mark Hallett [États-Unis] ; John Nutt [États-Unis] ; Lorraine Ramig [États-Unis] ; Terence Sanger [États-Unis] ; Allan D. Wu [États-Unis] ; Peter H. Kraus [Allemagne] ; Lucia M. Blasucci [États-Unis] ; Ejaz A. Shamim [États-Unis] ; Kapil D. Sethi [États-Unis] ; Jennifer Spielman [États-Unis] ; Ken Kubota [États-Unis] ; Andrew S. Grove [États-Unis] ; Eric Dishman [États-Unis] ; C. Barr Taylor [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Ordinateur, Technologie.
English descriptors
- KwdEn :
- Accelerometer, Aged, At home, Biomechanical Phenomena, Computer, Computer-Aided Design, Disability Evaluation, Feasibility, Feasibility Studies, Female, Humans, Hypokinesia (diagnosis), Hypokinesia (etiology), Male, Middle Aged, Nervous system diseases, Neurologic Examination (methods), Outcome Assessment (Health Care), Parkinson Disease (complications), Parkinson Disease (etiology), Parkinson disease, Parkinson's disease, Patient Satisfaction (statistics & numerical data), Reproducibility of Results, Severity of Illness Index, Technology, Tremor, Tremor (diagnosis), Tremor (etiology), accelerometer, bradykinesia, computer‐based technology, tremor.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Hypokinesia, Tremor.
- etiology : Hypokinesia, Parkinson Disease, Tremor.
- methods : Neurologic Examination.
- statistics & numerical data : Patient Satisfaction.
- Aged, Biomechanical Phenomena, Computer-Aided Design, Disability Evaluation, Feasibility Studies, Female, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Reproducibility of Results, Severity of Illness Index.
Abstract
We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society
Url:
- https://api.istex.fr/document/909FDE21B6C19AF13F9C08E1C3796068E9748DB3/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161502
DOI: 10.1002/mds.22379
Affiliations:
- Allemagne, États-Unis
- Californie, Colorado, District de Columbia, Géorgie (États-Unis), Illinois, Maryland, Oregon
- Washington (district de Columbia)
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Le document en format XML
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Goetz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Wolff, David" sort="Wolff, David" uniqKey="Wolff D" first="David" last="Wolff">David Wolff</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kinetics Foundation, Los Altos, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Deleeuw, William" sort="Deleeuw, William" uniqKey="Deleeuw W" first="William" last="Deleeuw">William Deleeuw</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Intel Corporation, Santa Clara, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bronte Tewart, Helen" sort="Bronte Tewart, Helen" uniqKey="Bronte Tewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Elble, Rodger" sort="Elble, Rodger" uniqKey="Elble R" first="Rodger" last="Elble">Rodger Elble</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, School of Medicine, Southern Illinois University, Springfield, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Oregon Health Sciences University, Portland, Oregon</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Ramig, Lorraine" sort="Ramig, Lorraine" uniqKey="Ramig L" first="Lorraine" last="Ramig">Lorraine Ramig</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Speech, Language, and Hearing Science, University of Colorado, Boulder, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Center for Voice and Speech, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Sanger, Terence" sort="Sanger, Terence" uniqKey="Sanger T" first="Terence" last="Sanger">Terence Sanger</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Comprehensive Movement Disorder Center, Stanford University, Palo Alto, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of California, Los Angeles, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Univerität Bochum, Bochum</wicri:regionArea><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Blasucci, Lucia M" sort="Blasucci, Lucia M" uniqKey="Blasucci L" first="Lucia M." last="Blasucci">Lucia M. Blasucci</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Motor Control Section, NINDS, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Georgetown University Hospital, Washington DC</wicri:regionArea><placeName><settlement type="city">Washington (district de Columbia)</settlement><region type="state">District de Columbia</region></placeName></affiliation></author><author><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D." last="Sethi">Kapil D. Sethi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Medical College of Georgia, Augusta, Georgia</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Spielman, Jennifer" sort="Spielman, Jennifer" uniqKey="Spielman J" first="Jennifer" last="Spielman">Jennifer Spielman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Center for Voice and Speech, Denver, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kinetics Foundation, Los Altos, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Grove, Andrew S" sort="Grove, Andrew S" uniqKey="Grove A" first="Andrew S." last="Grove">Andrew S. Grove</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Intel Corporation, Santa Clara, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dishman, Eric" sort="Dishman, Eric" uniqKey="Dishman E" first="Eric" last="Dishman">Eric Dishman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Intel Corporation, Santa Clara, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Taylor, C Barr" sort="Taylor, C Barr" uniqKey="Taylor C" first="C. Barr" last="Taylor">C. Barr Taylor</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Kinetics Foundation, Los Altos, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15">2009-03-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="551">551</biblScope><biblScope unit="page" to="556">556</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">909FDE21B6C19AF13F9C08E1C3796068E9748DB3</idno><idno type="DOI">10.1002/mds.22379</idno><idno type="ArticleID">MDS22379</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accelerometer</term><term>Aged</term><term>At home</term><term>Biomechanical Phenomena</term><term>Computer</term><term>Computer-Aided Design</term><term>Disability Evaluation</term><term>Feasibility</term><term>Feasibility Studies</term><term>Female</term><term>Humans</term><term>Hypokinesia (diagnosis)</term><term>Hypokinesia (etiology)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurologic Examination (methods)</term><term>Outcome Assessment (Health Care)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (etiology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Patient Satisfaction (statistics & numerical data)</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Technology</term><term>Tremor</term><term>Tremor (diagnosis)</term><term>Tremor (etiology)</term><term>accelerometer</term><term>bradykinesia</term><term>computer‐based technology</term><term>tremor</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypokinesia</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Patient Satisfaction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Biomechanical Phenomena</term><term>Computer-Aided Design</term><term>Disability Evaluation</term><term>Feasibility Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Outcome Assessment (Health Care)</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>A domicile</term><term>Accéléromètre</term><term>Faisabilité</term><term>Maladie de Parkinson</term><term>Ordinateur</term><term>Pathologie du système nerveux</term><term>Technologie</term><term>Tremblement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Ordinateur</term><term>Technologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We tested the feasibility of a computer based at‐home testing device (AHTD) in early‐stage, unmedicated Parkinson's disease (PD) patients over 6 months. We measured compliance, technical reliability, and patient satisfaction to weekly assessments of tremor, small and large muscle bradykinesia, speech, reaction/movement times, and complex motor control. relative to the UPDRS motor score. The AHTD is a 6.5″ × 10″ computerized assessment battery. Data are stored on a USB memory stick and sent by internet to a central data repository as encrypted data packets. Although not designed or powered to measure change, the study collected data to observe patterns relative to UPDRS motor scores. Fifty‐two PD patients enrolled, and 50 completed the 6 month trial, 48 remaining without medication. Patients complied with 90.6% of weekly 30‐minute assessments, and 98.5% of data packets were successfully transmitted and decrypted. On a 100‐point scale, patient satisfaction with the program at study end was 87.2 (range: 80–100). UPDRS motor scores significantly worsened over 6 months, and trends for worsening over time occurred for alternating finger taps (P = 0.08), tremor (P = 0.06) and speech (P = 0.11). Change in tremor was a significant predictor of change in UPDRS (P = 0.047) and was detected in the first month of the study. This new computer‐based technology offers a feasible format for assessing PD‐related impairment from home. The high patient compliance and satisfaction suggest the feasibility of its incorporation into larger clinical trials, especially when travel is difficult and early changes or frequent data collection are considered important to document. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li><li>District de Columbia</li><li>Géorgie (États-Unis)</li><li>Illinois</li><li>Maryland</li><li>Oregon</li></region><settlement><li>Washington (district de Columbia)</li></settlement></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G." last="Goetz">Christopher G. Goetz</name></region><name sortKey="Blasucci, Lucia M" sort="Blasucci, Lucia M" uniqKey="Blasucci L" first="Lucia M." last="Blasucci">Lucia M. Blasucci</name><name sortKey="Bronte Tewart, Helen" sort="Bronte Tewart, Helen" uniqKey="Bronte Tewart H" first="Helen" last="Bronte-Stewart">Helen Bronte-Stewart</name><name sortKey="Deleeuw, William" sort="Deleeuw, William" uniqKey="Deleeuw W" first="William" last="Deleeuw">William Deleeuw</name><name sortKey="Dishman, Eric" sort="Dishman, Eric" uniqKey="Dishman E" first="Eric" last="Dishman">Eric Dishman</name><name sortKey="Elble, Rodger" sort="Elble, Rodger" uniqKey="Elble R" first="Rodger" last="Elble">Rodger Elble</name><name sortKey="Grove, Andrew S" sort="Grove, Andrew S" uniqKey="Grove A" first="Andrew S." last="Grove">Andrew S. Grove</name><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><name sortKey="Kubota, Ken" sort="Kubota, Ken" uniqKey="Kubota K" first="Ken" last="Kubota">Ken Kubota</name><name sortKey="Nutt, John" sort="Nutt, John" uniqKey="Nutt J" first="John" last="Nutt">John Nutt</name><name sortKey="Ramig, Lorraine" sort="Ramig, Lorraine" uniqKey="Ramig L" first="Lorraine" last="Ramig">Lorraine Ramig</name><name sortKey="Ramig, Lorraine" sort="Ramig, Lorraine" uniqKey="Ramig L" first="Lorraine" last="Ramig">Lorraine Ramig</name><name sortKey="Sanger, Terence" sort="Sanger, Terence" uniqKey="Sanger T" first="Terence" last="Sanger">Terence Sanger</name><name sortKey="Sethi, Kapil D" sort="Sethi, Kapil D" uniqKey="Sethi K" first="Kapil D." last="Sethi">Kapil D. Sethi</name><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name><name sortKey="Spielman, Jennifer" sort="Spielman, Jennifer" uniqKey="Spielman J" first="Jennifer" last="Spielman">Jennifer Spielman</name><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T." last="Stebbins">Glenn T. Stebbins</name><name sortKey="Taylor, C Barr" sort="Taylor, C Barr" uniqKey="Taylor C" first="C. Barr" last="Taylor">C. Barr Taylor</name><name sortKey="Wolff, David" sort="Wolff, David" uniqKey="Wolff D" first="David" last="Wolff">David Wolff</name><name sortKey="Wu, Allan D" sort="Wu, Allan D" uniqKey="Wu A" first="Allan D." last="Wu">Allan D. Wu</name></country><country name="Allemagne"><noRegion><name sortKey="Kraus, Peter H" sort="Kraus, Peter H" uniqKey="Kraus P" first="Peter H." last="Kraus">Peter H. Kraus</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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